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Find the right nootropic for your needs
Ashwagandha
Ashwagandha (Withania somnifera) is an ancient Ayurvedic adaptogenic herb renowned for its stress-reducing and neuroprotective properties. Widely used as a nootropic supplement, it helps enhance cognitive function, reduce anxiety, and improve overall mental resilience.
California Poppy
California Poppy (Eschscholzia californica) is a gentle sedative herb that interacts with GABA and opioid receptors to promote relaxation, reduce anxiety, and improve sleep quality - without the dependency risks of pharmaceutical sedatives.
5-HTP
5-HTP is a naturally occurring amino acid and direct precursor to serotonin, the neurotransmitter that regulates mood, sleep, and appetite. It is primarily used to support emotional well-being, reduce anxiety, improve sleep quality, and manage stress.
St. John's Wort
St. John's Wort (Hypericum perforatum) is one of the most extensively researched herbal remedies for mild to moderate depression. It contains active compounds hypericin and hyperforin that modulate serotonin, dopamine, and norepinephrine to support mood balance and emotional wellbeing.
Magnolia Bark
Magnolia bark is a traditional Chinese and Japanese medicinal herb containing the bioactive compounds honokiol and magnolol. These powerful polyphenols modulate GABA receptors to promote calm relaxation without sedation, reduce anxiety, support sleep quality, and provide neuroprotective antioxidant effects.
Phenibut
Phenibut is a synthetic GABA derivative developed in Russia that crosses the blood-brain barrier. It activates GABA-B receptors to produce anxiolytic, sedative, and mood-enhancing effects. While effective for anxiety, it carries substantial risks of dependence and withdrawal with regular use.
CBD (Cannabidiol)
CBD is a non-psychoactive cannabinoid from the cannabis plant with significant anxiolytic, neuroprotective, and anti-inflammatory properties. It modulates the endocannabinoid system, serotonin receptors, and GABA signalling to reduce anxiety, improve sleep, and protect brain health.
Kava Kava
Kava Kava (Piper methysticum) is a traditional South Pacific root herb renowned for its powerful anxiolytic and relaxation-promoting effects. Its active kavalactones modulate GABA receptors to reduce anxiety, promote sociability, and improve sleep - without impairing cognitive function.
Lemon Balm
Lemon Balm (Melissa officinalis) is a gentle calming herb from the mint family with over 2,000 years of traditional use. It reduces anxiety, promotes restful sleep, and may support memory and attention through GABA modulation and mild acetylcholinesterase inhibition.
Magnesium Glycinate
Magnesium glycinate is a highly bioavailable, chelated form of magnesium bound to the amino acid glycine, renowned for its superior absorption and gentle effect on the digestive system. It is widely used to support sleep quality, reduce stress and anxiety, and enhance cognitive function.
Tongkat Ali
Tongkat Ali (Eurycoma longifolia) is a traditional Southeast Asian herb known for supporting healthy testosterone levels, reducing stress hormones, and enhancing energy and libido. Research shows it can significantly improve the cortisol-to-testosterone ratio.
Selank
A synthetic peptide analogue of the endogenous immunomodulatory peptide tuftsin, developed in Russia as an anxiolytic and nootropic that modulates GABA and serotonin systems without sedation or dependence.
L-Theanine
An amino acid found naturally in tea leaves, L-Theanine promotes relaxation without drowsiness. It is widely used for reducing anxiety, improving focus, and enhancing sleep quality - often stacked with caffeine for calm, sustained attention.
Magnesium L-Threonate
A patented form of magnesium specifically designed to cross the blood-brain barrier, clinically shown to increase brain magnesium levels and improve memory, learning, and cognitive function.
Glycine
Glycine is the simplest amino acid, serving as an inhibitory neurotransmitter and a key building block for proteins, collagen, and glutathione. It promotes deep, restorative sleep, reduces anxiety, and supports cognitive function through NMDA receptor co-agonism.
Saffron (Crocus sativus)
The world's most expensive spice, saffron contains crocin and safranal - bioactive compounds with robust clinical evidence for improving mood, reducing anxiety, and supporting cognitive function.
Vitamin B6 (Pyridoxine)
Vitamin B6 is an essential vitamin involved in over 150 enzymatic reactions, including the synthesis of every major neurotransmitter - serotonin, dopamine, GABA, and norepinephrine. It supports mood balance, cognitive development, and healthy brain ageing.
Vitamin B8 (Inositol)
Inositol (often called vitamin B8, though technically not a true vitamin) is a carbocyclic sugar that plays a critical role in cell signalling, particularly in the serotonin and insulin pathways. It is widely used for anxiety, panic disorder, OCD, and mood support, with clinical evidence comparable to some prescription medications.
Lavender (Lavandula angustifolia)
A well-known aromatic herb whose standardised oral extract (Silexan/Lavela) has demonstrated anxiolytic efficacy comparable to benzodiazepines in clinical trials - without sedation, cognitive impairment, or dependence risk.
Polygala Tenuifolia (Yuan Zhi)
A cornerstone herb of Traditional Chinese Medicine used for over 2,000 years to "sharpen the mind and benefit the will" - modern research confirms its ability to enhance BDNF, improve memory, and reduce neuroinflammation.
Melatonin
Melatonin is a hormone naturally produced by the pineal gland that regulates the sleep-wake cycle. Supplemental melatonin is widely used to improve sleep onset, quality, and circadian rhythm alignment - with emerging evidence for neuroprotective and antioxidant benefits.
Reishi Mushroom
Reishi mushroom (Ganoderma lucidum) is a revered adaptogenic fungus that promotes calm, supports sleep quality, modulates the immune system, and reduces stress, making it a valued nootropic for relaxation and long-term brain health.
Black Seed Oil (Nigella Sativa)
Black Seed Oil, derived from Nigella sativa, is a traditional remedy containing the potent bioactive compound thymoquinone, which supports cognitive function, reduces inflammation, enhances mood, and provides broad-spectrum antioxidant protection for brain health.
GABA (Gamma-Aminobutyric Acid)
GABA is the brain's primary inhibitory neurotransmitter, responsible for calming neural activity. As a supplement, it is used to promote relaxation, reduce anxiety, improve sleep quality, and support a balanced mood without sedation.
L-Tryptophan
L-Tryptophan is an essential amino acid and the precursor to serotonin and melatonin. It supports mood balance, promotes healthy sleep, and helps regulate appetite - serving as the upstream building block for the brain's key calming and sleep-regulating neurotransmitters.
Passionflower
Passionflower (Passiflora incarnata) is a traditional herbal sedative used for centuries to relieve anxiety, promote sleep, and calm nervous restlessness. Its flavonoids enhance GABA activity for gentle, non-drowsy relaxation during the day and restful sleep at night.
Psychobiotics
Psychobiotics are specific strains of probiotic bacteria that produce measurable effects on brain function and mental health through the gut-brain axis. Research has identified particular strains of Lactobacillus and Bifidobacterium that can reduce anxiety, improve mood, enhance cognitive function, and modulate the stress response.
Apigenin
A flavonoid found abundantly in chamomile that inhibits CD38 to preserve NAD+ levels, promotes BDNF expression, modulates GABA receptors for anxiolytic effects, and supports healthy sleep architecture.
Omega-3 (DHA)
DHA is a long-chain omega-3 fatty acid constituting 20–30% of brain lipids. Essential for neuronal membrane integrity, synaptic plasticity, and neurotransmitter function - one of the most fundamentally important nutrients for cognitive health and neuroprotection.
Valerian
Valerian (Valeriana officinalis) is one of the most well-established herbal sedatives, used since ancient Greek and Roman times for insomnia and nervous restlessness. It increases GABA availability in the brain to promote deep, restorative sleep and reduce anxiety.